• Active antibiotic discontinuation in suspected but not confirmed early‐onset neonatal sepsis—A quality improvement initiative 

      Dretvik, Thomas Bruvoll; Solevåg, Anne Lee; Finvåg, Andreas; Størdal, Eline Hasselgård; Størdal, Ketil; Klingenberg, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-30)
      <i>Aim</i> - To study whether a simple targeted intervention could reduce unwarranted antibiotic treatment in near‐term and term neonates with suspected, but not confirmed early‐onset sepsis.<p> <p><i>Methods</i> - A quality improvement initiative in three Norwegian neonatal intensive care units. The intervention included an inter‐hospital clinical practice guideline for discontinuing antibiotics ...
    • Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America, and Australia 

      Giannoni, Eric; Dimopoulou, Varvara; Klingenberg, Claus Andreas; Navér, Lars; Nordberg, Viveka; Berardi, Alberto; El Helou, Salhab; Fusch, Gerhard; Bliss, Joseph M.; Lehnick, Dirk; Guerina, Nicholas; Seliga-Siwecka, Joanna; Maton, Pierre; Lagae, Donatienne; Mari, Judit; Janota, Jan; Agyeman, Philipp K A; Pfister, Riccardo; Latorre, Giuseppe; Maffei, Gianfranco; Laforgia, Nicola; Mózes, Eniko; Størdal, Ketil; Strunk, Tobias; Stocker, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-23)
      <p><b> IMPORTANCE</b> Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying early-life antibiotic exposure along with EOS incidence are needed to provide a basis for future interventions aimed at safely reducing neonatal ...
    • Antibiotic Use in Term and Near-Term Newborns 

      Mundal, Håkon S.; Rønnestad, Arild Erland; Klingenberg, Claus Andreas; Stensvold, Hans Jørgen; Størdal, Ketil (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-01)
      OBJECTIVES - We aimed to study whether national and local antibiotic stewardship projects have reduced the antibiotic use in newborns and to monitor potential changes in adverse outcomes.<p> <p>METHODS - In a nationwide, population-based study from Norway, we included all hospital live births from 34 weeks' gestation (n = 282 046) during 2015 to 2019. The primary outcome was the proportion of ...
    • Expired carbon dioxide during newborn resuscitation as predictor of outcome 

      Holte, Kari; Ersdal, Hege Langli; Klingenberg, Claus; Eilevstjønn, Joar; Stigum, Hein; Jatosh, Samwel; Kidanto, Hussein; Størdal, Ketil (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-03)
      <i>Aim</i> - To explore and compare expired CO<sub>2</sub> (ECO<sub>2</sub>) and heart rate (HR), during newborn resuscitation with bag-mask ventilation, as predictors of 24-h outcome.<br><br> <i>Methods</i> - Observational study from March 2013 to June 2017 in a rural Tanzanian hospital. Side-stream measures of ECO<sub>2</sub>, ventilation parameters, HR, clinical information, and 24-h outcome ...
    • Factors influencing growth of children aged 12-24 months in the Tanga Region, Tanzania 

      Elverud, Ingvild Skålnes; Størdal, Ketil; Chiduo, Mercy Grace; Klingenberg, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-23)
      <i>Background</i> - The first 1000 days of life, from conception to the second birthday, offer a unique window of opportunity for optimal growth, critical for future health. The primary aim of this study was to analyze growth of children between 12 and 24 months age in Tanzanian children, and to explore possible predictors for growth.<p> <p><i>Methods</i> - Observational, cross-sectional study ...
    • Less is more: Antibiotics at the beginning of life 

      Stocker, Martin; Klingenberg, Claus Andreas; Navér, Lars; Nordberg, Viveka; Berardi, Alberto; el Helou, Salhab; Fusch, Gerhard; Bliss, Joseph M.; Lehnick, Dirk; Dimopoulou, Varvara; Guerina, Nicholas; Seliga-Siwecka, Joanna; Maton, Pierre; Lagae, Donatienne; Mari, Judit; Janota, Jan; Agyeman, Philipp K. A.; Pfister, Riccardo; Latorre, Giuseppe; Maffei, Gianfranco; Laforgia, Nichola; Mózes, Enikő; Størdal, Ketil; Strunk, Tobias; Giannoni, Eric (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-27)
      Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise ...
    • Sars-CoV-2 hos barn og ungdom i Norge: Påvist smitte, sykehusinnleggelser og underliggende tilstander 

      Størdal, Ketil; Bakken, Inger Johanne Landsjøåsen; Greve-Isdahl, Margrethe; Klingenberg, Claus; Helland, Eyvind; Nystad, Wenche; Hjellvik, Vidar; Gulseth, Hanne Løvdal (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-24)
      BAKGRUNN - Barn og unge har lavere risiko for sykdom forårsaket av sars-CoV-2. Vi beskriver forekomsten av påvist smitte og innleggelser hos barn og unge under 20 år i Norge, og spesifikt blant dem med underliggende tilstander.<p> <p>MATERIALE OG METODE - Helsedirektoratet har i samarbeid med Folkehelseinstituttet etablert et datauttrekk for å overvåke koronavirusutbruddet. Data fra ...